Epithelial tumors are the most common
type of ovarian cancer comprising 85-90% of all ovarian cancers and
are derived from the epithelial (outside) lining of the ovary. This
tissue is contiguous with the tissue lining the remainder of the abdominal
cavity- the peritoneum. Thus Primary Peritoneal Cancer is thought
to either be the same, or at least very closely related to Epithelial
Ovarian Cancer. This type of ovarian cancer predominates in the later
decades of life, although is occasionally found in younger women as
well.
Germ Cell ovarian cancers are derived from the same
cells that form eggs for fertilization. Benign tumors from these cells
(dermoid, or mature teratomas) even have the capability to form such
tissues as teeth, skin, hair, etc. These cancers are more commonly
found in younger women and girls. They tend to grow more rapidly and
thus present with more symptoms than other types of ovarian cancer.
Sex Cord- Stromal tumors are derived either from
the connective tissue holding the ovary together (fibromas or fibrosarcomas)
or the cells that produce hormones from the ovary (granulosa or thecoma
cells). These tumors may produce male hormones that cause hirsutism
(male hair growth patterns), balding, acne, or deepening of the voice.
They may also produce estrogen (female hormones) and can cause thickening
of the lining of the uterus leading to pre-cancer (endometrial hyperplasia)
or cancer (endometrial cancer) of the uterus as well.
| CELL of ORIGIN |
Surface Epithelium |
Germ Cells |
Sex Cord – Stromal
Cells |
| Overall Frequency |
65-70% |
15-20% |
5-10% |
Proportion of Malignant
Ovarian Tumors |
90% |
3-5% |
2-3% |
| Age Group Affected
|
20+ years |
0-25+ years |
All ages |
| Histologic Types |
Papillary Serous
Endometrioid
Mucinous
Clear Cell
Mixed |
Teratoma
Dysgerminoma
Yolk Sac Tumor
Embryonal Cell Carcinoma
Choriocarcinoma |
Fibroma
Thecoma
Granulosa Cell |
|